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Cigarette smoke exposure elicits increased autophagy and dysregulation of mitochondrial dynamics in murine granulosa cells

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In agreement with that finding and the relative increase of MoAM in chronically smoke-exposed mice, these animals were characterized by impaired lung function as demonstrated by an upward shift of the pressure-volume loop that is typically seen in emphysematous mice ( Figure 6H ) ( Figures 6I, J )